Mercury and Heavy Metal Detoxification At It’s Best:

FOR MY MOST CURRENT RECOMMENDATIONS ON THE MOST EFFECTIVE WAY TO DETOXIFY MERCURY SEE NEWSLETTER ENTITLED: Doing This Will Help You To Detoxify Mercury and Decalcify the Pineal Gland

Quicksilver Scientific has developed a sophisticated detoxification system based on enhancing the natural removal of metals through the intestines using a proprietary compound, IMD (Intestinal Metals Detox).

IMD supplements the natural action of glutathione in the intestines by using insoluble thiol groups to bind and remove heavy metals accumulated in the intestines and to directly quench free-radicals.  IMD

• Binds mercury and other heavy metals in the intestines and escorts these harmful contaminants out of the body.
• Intercepts methylmercury trapped in enterohepatic circulation.

Binding and removal of intestinal heavy metals

• Leads to lowering of blood mercury levels, allowing organ and tissue bound mercury safely to drain into the blood at a natural rate (Figure 2).
• Improves the body’s natural detoxification ability by quenching free radicals and stopping metal-catalyzed free-radical reactions, which can otherwise lead to inflammation and cause down-regulation of detox transporters (Phase III transporters—OATs, cMOAT, MRPs, etc) ¹
• Fortifies the link between the intestines and the immune system.

Active Chemistry of IMD

The Intestinal Metals Detox (IMD) is a proprietary product that consists of highly purified silica with covalently attached metal-binding groups.  Both the silica base and the binding agent are GRAS (generally recognized as safe) for use in food. The specific chemistry of the compound has several benefits over other detoxification remedies.

• The active binding groups out–compete other compounds for metals in the intestines.
• Because IMD does not enter the bloodstream, it will not lead to spikes in blood mercury levels nor kidney of liver overload. In fact, preliminary data suggests increased liver functioning in some patients, as measured by changes in bilirubin levels.
• The chemistry of the attachment between binding groups and silica ensures the compound will not breakdown appreciably in the intestines.

Disruptions in Natural Body–wide Detoxification

Intestinal inflammation inhibits elimination of toxins by causing a strong down-regulation of the body’s natural detoxification pathways.¹ Ironically, exposure to certain toxins contributes to intestinal inflammation. For example, the corrosion of amalgam mercury results in mercuric mercury (Hg^II) release. When swallowed with saliva, Hg^II can cause intestinal inflammation and initiate this negative feedback.²

Healthy Detoxification

Detoxification processes occur throughout the body. A healthy detoxification pathway typically involves three phases. Phase I involves oxidative activation of a toxin, preparing the toxin for conjugation to a hydrophilic biomolecule in Phase II. The conjugate is then moved through a series of Phase III transporters, leading to intestinal or kidney excretion.

 

Impaired Detoxification (Figure 1, right)

Intestinal inflammation disrupts detoxification in two ways.

Inhibiting the conjugation of toxins throughout the body and inhibiting transport of toxins into the intestines. Intestinal inflammation down-regulates Phase III transporters. When transporters down-regulate, signals are sent to turn down Phase II activity.³ Phase I activity, however, does not get down-regulated. Phase I oxidation continues but is no longer coupled to Phase II conjugation.

Inhibiting glutathione activity in the intestines. Phase III transporters bring glutathione (GSH) into the intestines from the liver.⁴ GSH is the primary anti-oxidant for quenching free-radical reactions in the intestines.⁵ A deficiency of GSH is a symptom of inflammatory bowel diseases, including Crohn’s Disease.⁶ Thus down-regulation of Phase III transporters can be self-propagating as oxidative stress stops the flow of this crucial antioxidant.

Recent research at the Nestle Cancer Center in Switzerland⁸ examined genetic expression of the body’s detoxification pathways and found that the small intestine and the liver work together tightly to coordinate detoxification and metabolism. They also found that glutathione activity is predominantly modulated from the small intestine. This finding supports our model of Phase III transporters in the intestines controlling Phase II pathways and points to the centrality of the intestines in any detoxification protocol.

Data Supporting IMD

Clinical trials of IMD have revealed profound benefits of use: Individuals with various autoimmune disorders reported reversal of disease–related symptoms while experiencing a continuous decrease in blood mercury. Quantitative and qualitative data gathered during these initial clinical trials indicate that Quicksilver Scientific’s Intestinal Metals Detox (IMD) (1) continuously lowers blood mercury levels, intercepting mercury in the enterohepatic pathway, (2) optimizes transporters that move glutathione and conjugated toxins into the intestines for excretion, and (3) alleviates some symptoms of pervasive diseases.

Evidence of Lowering Blood Mercury

Small-scale clinical trials were conducted with patients undergoing dental revision. In Clinic 1, After 7 days of treatment with IMD, patients experienced an average 23.9% decrease in total blood mercury (Table 1), compared with very little change seen in people who did not use IMD. Similar decreases were seen in Clinic 2 when IMD was used alone or in combination with CTI Science’s OSR.

 

Long–term data from Dr. Christopher Shade shows that, in using IMD along with dental revision, blood levels of both methyl (MeHg) and inorganic mercury (Hg^II) decrease steadily over a period of months. Blood Hg^II shows a two-phase decrease with a rapid initial decrease followed by slower decrease (Figure 2). Fecal excretion data (not shown) reveals release and excretion from bodily stores (from 1/30^th to 1/10^th of the blood burden of MeHg excreted per day); with blood MeHg levels constantly equilibrating with and tracking the body burden.

 

These decreases are especially significant when comparing these results to a large-scale baseline study of patients undergoing dental revision without any detoxification.¹⁴ This study showed that total blood mercury levels did not decrease following revision. Dental revision actually lead to an increase in MeHg over time (Figure 3), whereas patients who did not undergo dental revision had stable levels of blood MeHg and Hg^II. The increase in blood MeHg after revision is consistent with our model: Following removal of the intestine’s mercury source (i.e. amalgam), activity of Phase II enzyme Glutathione S-Transferase increases and moves mercury out of cells into the bloodstream.

Evidence for Opening of Phase III Transporters

Bilirubin is a breakdown product of hemoglobin and accumulation of bilirubin in the blood is the cause of jaundice and generally considered to be a sign of poor liver function. Extensive experimentation has shown that the biggest problem in bilirubin excretion is failure of the Phase III transporters to remove the conjugated bilirubin from the liver and into the intestines.⁴ This is the same transporter that moves glutathione and glutathione conjugates (including mercury-glutathione¹⁵) into the intestines and sulfate conjugates into the urine.¹⁶ There is abundant anecdotal evidence of a connection between mercury toxicity and bilirubin buildup (as seen on Gilbert Syndrome Web Forums, where flare-ups of GS are cited after amalgam placements or unprotected amalgam removals).

 

In our trials of the IMD on patients that have recently had dental revision, we have found rapid and dramatic lowering of blood bilirubin in patients who had elevated levels. This data supports the idea that IMD opens Phase III transporters and consequently up-regulates Phase II conjunctions. It is most likely that Phase III transporters up-regulate as a result of reduction of the inflammation and metals in the gut (Figure 1).

 

 

Alleviation of Symptoms of Pervasive Disease

Quicksilver Scientific has received testimonials from dozens of patients who have experienced health benefits while using IMD. It is possible that alleviating toxic buildup in the intestines of these patients have lead to these increased feelings of wellness. These patients have had the following disease states:

• Alzheimer’s
• Leukemia
• Multiple Sclerosis
• Crohn’s Disease

Products Needed for Mercury Detoxification:

	Intestinal Metals Detox: needed to detoxify heavy metals from the intestinal lining. Once removed the enviorment is now improved so that all intestal inflammation can go away. Once intestinal inflammation goes away then you will have better absorption, immunity, energy, and ability to detoxify.
	Clear Way Cofactors supplies phenolic compounds and vitamins for the removal of heavy metals from the tissues of your body. In other words whole body detoxification assitance.
	Lipogenic EDTA with R-Lipoic Acid (aka Therasomal Vitamin C + R-lipoic acid) Supplies EDTA and R-Lipic acid in liposomal forms so that they can be absorbed much better and two act as direct powerful chelators or removers of mercury and heavy metals.
	Liposomal Glutathione Goes inside the cell to act as a direct heavy metal detoxifier or remover. It also protects the cells from free radicals one of the proposed causes of aging.
	Liposomal C also goes inside the cell to assist in mercury detox and free radical protection. Getting in inside the cell is the key and the reason for delivering it in the liposomal form.
	Buffered Vitamin Ascorbic Acid (This product is optional if using Liposomal C only. Some people alternate between the two to make more affordable the process or subsitute this Alka C for the Liposomal C in an effort to save money. Liposomal C is much stronger at raising acsorbic acid levels inside the cell and therefore more theraputic).
	Mineral Magic is needed to make metabolic enzymes that are essential to being able to detoxify heavy metals. It is also needed to replace the cellular openings that occur when Mercury comes off the tissue site. Once the nutritive mineral replaces the mercury the cell can become fully operational again. Take 1tsp of Mineral Magic on Saturday and Sunday.

You should use all the above products except Mineral Magic, 5 days on and two days off. On the 2 days off you should take 1tsp of Mineral Magic each day.

Start Here: It is not required to begin with a heavy metal test before you begin to detoxify heavy metals. If you need to save money and put it directly into the supplements needed to detox then that is my recommendation that you do that. That is what I would do. However if you want to track your progress and document your results then the Mercury Tri Test is required. For everyone else go ahead and get started on the Mercury Detox Kit.

1. Get tested to see the two different types of mercury your body is burdened with and the amounts. This test is measures the blood, hair and urine in parts per trillion. It is the most accurate method of mercury yet developed. (To purchase test kit click here)
2. For explanation of test kit click here.
3. See IMD Use instructions Page for dosage and frequency

 

DISCLAIMER

Quicksilver Scientific does not imply that IMD will treat any disease. The information presented in this document is designed to aid health practitioners by synthesizing multiple studies on the body’s detoxification pathways. References and further information on our clinical studies, received testimonials, and plans for future studies, are available upon request.